STORY BEHIND THE SCIENCE

The story behind Neuro-Bio comes from the passion for research from Baroness Professor Susan Greenfield, each step comes together almost like a puzzle piece.

  • Acetylcholinesterase (AChE) present in neuronal and non-neuronal cells without its normal substrate (acetylcholine): need not function as an enzyme!
  • AChE released into cerebrospinal fluid and detectable locally from brain areas linked to neurodegeneration: this release visualised in real-time and monitored on-line in the moving animal.
  • Even when its enzymatic site is irreversibly blocked, AChE still has electrophysiogical, biochemical/pharmacological, and behavioural actions.
  • This novel, non-enzymatic function of AChE promotes cell growth via modulation of calcium influx.
  • BUT in high doses, or for a long administration, the growth (‘trophic’) action of AChE can turn toxic.
  • The key part of the AChE molecule is identified as a 14mer peptide at the AChE C-terminus, ‘T14’
        (a) homology to amyloid-beta
        (b) independently enhances calcium currents, which in turn.
        (c) can have a trophic-toxic, ‘excitotoxic’ action.
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