STORY BEHIND THE SCIENCE
The story behind Neuro-Bio comes from the passion for research from Baroness Professor Susan Greenfield, each step comes together almost like a puzzle piece.

- Acetylcholinesterase (AChE) present in neuronal and non-neuronal cells without its normal substrate (acetylcholine): need not function as an enzyme!
- AChE released into cerebrospinal fluid and detectable locally from brain areas linked to neurodegeneration: this release visualised in real-time and monitored on-line in the moving animal.
- Even when its enzymatic site is irreversibly blocked, AChE still has electrophysiogical, biochemical/pharmacological, and behavioural actions.
- This novel, non-enzymatic function of AChE promotes cell growth via modulation of calcium influx.
- BUT in high doses, or for a long administration, the growth (‘trophic’) action of AChE can turn toxic.
- The key part of the AChE molecule is identified as a 14mer peptide at the AChE C-terminus, ‘T14’
- (a) homology to amyloid-beta
- (b) independently enhances calcium currents, which in turn.
- (c) can have a trophic-toxic, ‘excitotoxic’ action.
Neuro-Bio Ltd
Building F5
Culham Science Centre
Abingdon
Oxfordshire
OX14 3DB
United Kingdom
Building F5
Culham Science Centre
Abingdon
Oxfordshire
OX14 3DB
United Kingdom
+44 (0) 1235 420 085
info@neuro-bio.com
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