A Novel Peptide Increased in Alzheimer’s Brain

The presence the acetylcholinesterase (AChE) enzyme is characteristic in the vulnerable ‘hub’ cells, including those initially lost in Parkinson’s Disease, where it is present in the absence of its normal substrate and co-localised with a range of different transmitters. This suggests it has an alternative function as a developmental signalling molecule that in the context of the adult brain shifts to acting as a toxic molecule as a result of its cleavage. This non-classical action is mediated by a peptide fragment cleaved from the carboxy-terminus of AChE (AChE-peptide), levels of which Neuro-Bio has shown are highest in the developing brain and increased again in the Alzheimer’s Disease brain (see Figure below).